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CpG-binding protein; PHD finger & CXXC domain-containing protein 1; CXXC finger protein 1 (CXXC1, CGBP, PCCX1, PHF18)

Function: 1) transcriptional activator 2) binding specificity for unmethylated CpG motifs - preference for CpGG [1] 3) may be regulated by proteolysis 4) component of the SET1 complex 5) interacts with SETD1A 6) interacts with ZNF335 Structure: - the acidic domain carries the potential to activate transcription - contains 1 CXXC-type Zn+2 finger - contains 1 PHD-type Zn+2 finger Compartment: - nuclear speckles - associated with euchromatin - during mitosis, excluded from condensed chromosomes Alternative splicing: named isoforms=2 Expression: ubiquitous

Related

CpG island, GC-rich element or GC box

General

nuclear protein phosphoprotein zinc finger protein

Properties

SIZE: MW = 76 kD entity length = 656 aa COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S6} Ser phosphorylation site {S19} Zn finger PHD-type NAME: Zn finger PHD-type SITE: 28-76 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 160-209 EFFECTOR-BOUND: Zn+2 Thr phosphorylation site {T227} acidic region {256-317} MOTIF: acidic residue (SEVERAL) lysine-rich region {321-359} MOTIF: lysine residue (SEVERAL) coiled coil {422-474}

Database Correlations

OMIM 609150 UniProt Q9P0U4 PFAM correlations Entrez Gene 30827 Kegg hsa:30827

References

  1. UniProt :accession Q9P0U4
  2. PMID: 17355966
  3. PMID: 17998332
  4. PMID: 18838538
  5. PMID: 21407193
  6. PMID: 23178126

Component-of

Set1/Ash2 histone methyltransferase (HMT) complex