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corticotropin-releasing factor/hormone [CRF/CRH] receptor
Function:
- receptor for corticotropin releasing factor
- high-affinity CRF binding
- activity is mediated by G proteins which activate adenylyl cyclase
Structure: belongs to the G-protein coupled receptor 2 family
Compartment: cell membrane
Related
corticotropin-releasing factor; corticoliberin; CRF; corticotropin-releasing hormone (CRH)
Specific
corticotropin-releasing factor receptor 1; CRF-R; CRF1; corticotropin-releasing hormone receptor 1; CRH-R 1 (CRHR1 CRFR CRFR1 CRHR)
corticotropin-releasing factor receptor 2; CRF-R 2; CRF2; corticotropin-releasing hormone receptor 2; CRH-R 2 (CRHR2 CRF2R CRH2R)
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: MW = 58-75 kD
COMPARTMENT: plasma membrane
CELL: neuron
WITHIN: brain
pituitary
ORGANISM: mammal*
unspecified cell type
WITHIN: spleen
MOTIF: exoplasmic domain {N-TERMINAL}
MOTIF: glycosylation site {N-TERMINAL}
cysteine-rich region {N-TERMINAL}
glycosylation site
transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
transmembrane domain {TM4}
transmembrane domain {TM5}
transmembrane domain {TM6}
transmembrane domain {TM7}
binding site
SITE: C-TERMINAL-CYS
EFFECTOR-BOUND: palmitate
BOUND-VIA: carboxylate
cytoplasmic domain {C-TERMINAL}
MISC-INFO: Kd [CRF] 0.2-0.4 NM
References
DeSouza et al Psychopharmacol Bull 1989;25(3):299-305