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Src substrate cortactin; amplaxin; oncogene EMS1 (CTTN EMS1)
Function:
- organization of cell structure
- associated with actin/integrin focal contacts
- may associate with Shank at the post synaptic density [3]
- substrate for the pp60v-src tyrosine kinase
- role in synaptic plasticity by mediating the local assembly of cytoskeleton & interacting with the NMDA receptor & PSD-95 [4]
- SH3 motif may function as a binding region to cytoskeleton
- interacts with SHANK2 & SHANK3 via its SH2 domain
- interacts with FGD1 (putative)
- interacts with PLXDC2
Structure:
- contains 7 cortactin repeats
- contains 1 SH3 domain
Compartment:
- cytoplasm, cytoskeleton (putative)
- cell projection, lamellipodium (putative)
- cell projection, ruffle (putative)
- associated with membrane ruffles & lamellipodia (putative)
Pathology:
- Tyr phosphorylation in transformed cells may contribute to cellular growth regulation & transformation
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: entity length = 550 aa
MW = 62 kD
COMPARTMENT: cytoplasm
MOTIF: Cortactin {80-116}
MOTIF: Ser phosphorylation site {S113}
Cortactin {117-153}
MOTIF: Ser phosphorylation site {S117}
Tyr phosphorylation site {Y141}
Cortactin {154-190}
Cortactin {191-227}
MOTIF: Tyr phosphorylation site {Y215}
Cortactin {228-264}
Cortactin {265-301}
Cortactin {302-324}
Tyr phosphorylation site {Y334}
Thr phosphorylation site {T399}
Thr phosphorylation site {T401}
Ser phosphorylation site {S405}
Thr phosphorylation site {T411}
Ser phosphorylation site {S417}
Ser phosphorylation site {S418}
Tyr phosphorylation site {Y421}
Tyr phosphorylation site {Y446}
Tyr phosphorylation site {Y453}
src homology 3 [SH3] domain
SITE: 492-550
Database Correlations
OMIM 164765
UniProt Q14247
PFAM correlations
Entrez Gene 2017
References
- Stossel TP.
On the crawling of animal cells.
Science. 1993 May 21;260(5111):1086-94. Review.
PMID: 8493552
- T. Maciag Holland Laboratory, American Red Cross,
Bethesda, MD
- Sheng M.
Molecular organization of the postsynaptic specialization.
Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7058-61. Review.
PMID: 11416187
- Rampon C, Jiang CH, Dong H, Tang YP, Lockhart DJ, Schultz PG,
Tsien JZ, Hu Y.
Effects of environmental enrichment on gene expression in the
brain.
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12880-4.
PMID: 11070096
- UniProt :accession Q14247
- Wikipedia; Note: cortactin entry
http://en.wikipedia.org/wiki/cortactin