corepressor complex

Structure: - complex contains about 20 different proteins - subunits include: - CTBP1, CTBP2, HDAC1, HDAC2, LCOR, RCOR3, BRMS1, BRMS1L, ING2/ING1, BANP, HDAC1, SIN3A, SIN3B, RBL1 & RBL2

Properties

COMPARTMENT: endosome SUBUNITS: C-terminal-binding protein 1 COMPARTMENT: cytoplasm cell nucleus MOTIF: GLIS2 interaction {1-70} binding site SITE: 100-100 FOR-BINDING-OF: NAD binding site SITE: 204-204 FOR-BINDING-OF: NAD arginine residue {R266} GLIS2 interaction {288-360} MOTIF: binding site SITE: 290-290 FOR-BINDING-OF: NAD glutamate residue {E295} Ser phosphorylation site {S300} histidine residue {H315} Ser phosphorylation site {S422} C-terminal-binding protein 2 COMPARTMENT: cell nucleus MOTIF: binding site SITE: 106-106 FOR-BINDING-OF: NAD cofactor-binding site [186-191] COFACTOR-BOUND: NAD cofactor-binding site [210-210] COFACTOR-BOUND: NAD cofactor-binding site [243-249] COFACTOR-BOUND: NAD cofactor-binding site [270-272] COFACTOR-BOUND: NAD MOTIF: arginine residue {R272} cofactor-binding site [296-296] COFACTOR-BOUND: NAD glutamate residue {E301} cofactor-binding site [321-324] COFACTOR-BOUND: NAD MOTIF: histidine residue {H321} Ser phosphorylation site {S428} histone deacetylase 1 COMPARTMENT: cell nucleus MOTIF: Histone deacetylase {9-321} MOTIF: histidine residue {H141} Tyr phosphorylation site {Y221} Ser phosphorylation site {S393} Ser phosphorylation site {S421} Ser phosphorylation site {S423} binding site FOR-BINDING-OF: retinoblastoma-associated protein histone deacetylase 2 COMPARTMENT: cell nucleus MOTIF: Histone deacetylase {9-322} MOTIF: histidine residue {H142} glycine-rich region {300-303} Ser phosphorylation site {S394} Ser phosphorylation site {S407} Ser phosphorylation site {S422} Ser phosphorylation site {S424} ligand-dependent corepressor COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S37} Thr phosphorylation site {T40} Ser phosphorylation site {S42} Thr phosphorylation site {T44} Interaction with nuclear receptors {53-57} nuclear translocation signal {339-345} HTH psq-type {340-392} MOTIF: Ser phosphorylation site {S351} Ser phosphorylation site {S359} Ser phosphorylation site {S363} Ser phosphorylation site {S367} DNA-binding motif SITE: 368-388 Ser phosphorylation site {S430} REST corepressor 3 COMPARTMENT: cell nucleus MOTIF: ELM2 {1-83} SANT 1 {85-133} coiled coil {237-273} SANT 2 {286-334} proline-rich region SITE: 385-481 MOTIF: proline residue (SEVERAL) breast cancer metastasis-suppressor 1 COMPARTMENT: cytoplasm cell nucleus breast cancer metastasis-suppressor 1-like protein COMPARTMENT: cell nucleus MOTIF: coiled coil {52-84} coiled coil {149-180} inhibitor of growth protein 2 COMPARTMENT: cytoplasm cell nucleus MOTIF: coiled coil {48-120} Zn finger PHD-type NAME: Zn finger PHD-type SITE: 212-261 EFFECTOR-BOUND: Zn+2 MOTIF: binding site SITE: 214-214 FOR-BINDING-OF: Histone H3K4me3 binding site SITE: 225-225 FOR-BINDING-OF: Histone H3K4me3 binding site SITE: 229-229 FOR-BINDING-OF: Histone H3K4me3 binding site SITE: 237-237 FOR-BINDING-OF: Histone H3K4me3 PBR {264-280} protein BANP COMPARTMENT: cell nucleus MOTIF: coiled coil {79-116} CUTL1 & HDAC1 interaction {178-368} Necessary & sufficient for TP53 activation {346-375} binding site SITE: 368-419 FOR-BINDING-OF: deoxyribonucleic acid (DNA) glutamine-rich region {387-452} MOTIF: glutamine residue (SEVERAL) histone deacetylase 1 COMPARTMENT: cell nucleus MOTIF: Histone deacetylase {9-321} MOTIF: histidine residue {H141} Tyr phosphorylation site {Y221} Ser phosphorylation site {S393} Ser phosphorylation site {S421} Ser phosphorylation site {S423} binding site FOR-BINDING-OF: retinoblastoma-associated protein paired amphipathic helix protein sin3a COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S10} HCFC1 interaction {119-196} MOTIF: paired amphipathic helix {119-189} REST interaction {205-480} MOTIF: proline-rich region SITE: 218-285 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S277} Ser phosphorylation site {S289} paired amphipathic helix {300-383} paired amphipathic helix {456-525} MOTIF: SAP30 interaction {458-525} NCOR1 interaction {523-850} MOTIF: SUDS3/SAP130 interaction {524-659} HDAC1/ARID4B interaction {687-829} Ser phosphorylation site {S832} glutamate-rich region {835-841} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S860} OGT interaction {888-967} MOTIF: coiled coil {903-932} Ser phosphorylation site {S940} Ser phosphorylation site {S1108} Ser phosphorylation site {S1112} paired amphipathic helix protein sin3b COMPARTMENT: cell nucleus MOTIF: paired amphipathic helix {37-107} MOTIF: REST interaction {59-105} paired amphipathic helix {153-238} NCOR1 interaction {284-540} MOTIF: paired amphipathic helix {292-369} SDS3 and HDAC1 interaction {392-591} retinoblastoma-associated protein-like p107 homolog COMPARTMENT: cell nucleus MOTIF: Thr phosphorylation site {T332} Thr phosphorylation site {T369} Pocket NAME: Pocket SITE: 385-949 FOR-BINDING-OF: nucleolar transcription factor 1 SV40 T antigen adenovirus E1a E2F MOTIF: Domain A {385-584} Thr phosphorylation site {T385} Spacer {585-780} Ser phosphorylation site {S640} Ser phosphorylation site {S650} Ser phosphorylation site {S762} Domain B {781-949} Ser phosphorylation site {S964} Ser phosphorylation site {S975} Ser phosphorylation site {S988} Thr phosphorylation site {T997} Ser phosphorylation site {S1009} Rb-related p130 COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 9-16 MOTIF: proline residue (SEVERAL) alanine-rich region {17-20} MOTIF: alanine residue (SEVERAL) glutamate-rich region {23-26} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S413} Pocket; binds E1A {417-1024} MOTIF: Thr phosphorylation site {T417} Ser phosphorylation site {S639} Thr phosphorylation site {T642} Ser phosphorylation site {S672} Ser phosphorylation site {S948} Ser phosphorylation site {S952} Ser phosphorylation site {S966} Ser phosphorylation site {S971} Ser phosphorylation site {S972} Ser phosphorylation site {S973} Thr phosphorylation site {T974} Ser phosphorylation site {S981} Ser phosphorylation site {S982} Thr phosphorylation site {T986} glutamate-rich region {998-1001} MOTIF: glutamate residue (SEVERAL) Thr phosphorylation site {T1019} STATE: active state

Components

breast cancer metastasis-suppressor 1 (BRMS1) breast cancer metastasis-suppressor 1-like protein (BRMS1-homolog protein p40, BRMS1-like protein p40, BRMS1L) C-terminal-binding protein 1 (CtBP1, CTBP) C-terminal-binding protein 2 (CtBP2) histone deacetylase 1 (reduced potassium dependency 3 [RPD3] homolog-like 1, HDAC1, RPD3L1) histone deacetylase 2 (HDAC2) inhibitor of growth protein 2; inhibitor of growth 1-like protein; ING1Lp; p32; p33ING2 (ING2, ING1L) ligand-dependent corepressor; LCoR; Mblk1-related protein 2 (LCOR, KIAA1795, MLR2) paired amphipathic helix protein sin3a; murine yeast transcription repressor Sin3 homolog; transcriptional corepressor Sin3a; histone deacetylase complex subunit Sin3a (SIN3A, mSin3A) paired amphipathic helix protein sin3b; histone deacetylase complex subunit sin3b; transcriptional corepressor sin3b (SIN3B, KIAA0700, msin3B) protein BANP (Btg3-associated nuclear protein, scaffold/matrix-associated region-1-binding protein, BANP, SMAR1) Rb-related protein p130; retinoblastoma-like protein 2; RBR-2; PRB2; 130 kD retinoblastoma-associated protein; p130 (RBL2 RB2) REST corepressor 3 ( RCOR3, KIAA1343) retinoblastoma-associated protein-like p107 homolog; retinoblastoma-like protein 1; PRB1; 107 kD retinoblastoma-associated protein; p107 (RBL1)