coordinator of PRMT5 & differentiation stimulator; cooperator of PRMT5; protein TTP1 (COPRS, C17orf79, COPR5)

Function: - histone-binding protein - required for histone H4 methyltransferase activity of PRMT5 - specifically required for histone H4 Arg-3 methylation mediated by PRMT5 - not required for histone H3 Arg-8 methylation - likely modulates substrate specificity of PRMT5 - specifically interacts with the N-terminus of histone H4, but not with histone H3, suggesting that it acts by promoting the association between histone H4 & PRMT5 - role in CCNE1 promoter repression - role in muscle cell differentiation - modulates recruitment of PRMT5 to promoterd of genes involved in coordination between cell cycle exit & muscle differentiation (putative) - interacts with PRMT5 - interacts with histone H4 - specifically interacts with the N-terminus of histone H4 but not with histone H3 - interacts with CBFB (putative) - found in a complex with PRMT5, RUNX1 & CBFB (putative) Compartment: nucleus

Properties

SIZE: entity length = 184 aa MW = 20 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl

Database Correlations

UniProt Q9NQ92 Entrez Gene 55352 Kegg hsa:55352

References

UniProt :accession Q9NQ92