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contact system
The contact system is a biochemical process that triggers local activation of several proteolytic systems. It plays a role in initiation & amplification of surface-mediated inflammatory processes via:
1) activation of:
a) complement C1
b) coagulation factor XI (intrinsic pathway of coagulation)
c) coagulation factor XII (intrinsic pathway of coagulation)
d) prorenin
e) plasminogen
f) prekallikrein
2) cleavage of HMW kininogen
-> release of bradykinin
General
biochemistry
References
- Bergamaschini L, Donarini C, Gobbo G, Parnetti L,
Gallai V.
Activation of complement and contact system in Alzheimer's
disease.
Mech Ageing Dev. 2001 Nov;122(16):1971-83.
PMID: 11589915