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connexin (gap-junction protein)

Function: - Ca+2/calmodulin & Tyr phosphorylation may mediate gap junction closure Structure: - two hexamers in plasma membranes of juxtaposed cells form a gap junction

Related

nexin

Specific

gap junction epsilon-1 protein (connexin-23, Cx23, GJE1) connexin-25 (connexin-25, Cx25, GJB7, CX25) connexin-26; gap junction protein beta-2 (CX26, GJB2) connexin-30.3; gap junction protein beta-4 (CX30.3, GJB4) connexin-30; gap junction protein beta-6 (CX30, GJB6) connexin-31.1 (CX31.1) or gap junction protein beta-5 gap junction gamma-3 protein (gap junction epsilon-1 protein, connexin-31.3, Cx31.3, GJC3, GJE1) connexin-31; gap junction protein beta-3 (CX31) connexin-32; gap junction protein beta-1 (CX32, GJB1) connexin-36; gap junction protein alpha-9 (CX36, GJA9, GJD2) connexin-37; gap junction protein alpha-4 (CX37, GJA4) connexin-40; gap junction protein alpha-5 (CX40) connexin-43; gap junction protein alpha-1 (CX43) connexin-45; gap junction protein alpha-6 (CX45) connexin-46; gap junction protein alpha-3 (GJA3, CX46) connexin-47; gap junction alpha-12 protein; Cx47; connexin-46.6; Cx46.6 (GJA12, GJC2) connexin-50; gap junction protein alpha-8 (CX50) gap junction alpha-10 protein; connexin-62 (GJA10, CX62) gap junction alpha-9 protein; connexin-58; connexin-59 (GJA9, GJA10; Cx58, Cx59) gap junction delta-3 protein; gap junction chi-1 protein; gap junction alpha-11 protein; connexin 31.9 (Cx31.9, GJD3, GJA11, GJC1)

General

calmodulin binding protein channel oligomerizing protein PEST protein plasma membrane protein transmembrane 4 protein

Properties

CONFIGURATION: hexamer SIZE: MW = 28-32 kD COMPARTMENT: plasma membrane MOTIF: cytoplasmic domain {N-TERMINAL} transmembrane domain {TM1} exoplasmic loop MOTIF: cysteine residue {C1} MODIFICATION: cysteine residue {C2} cysteine residue {C2} MODIFICATION: cysteine residue {C1} LOOP#: 1 transmembrane domain {TM2} cytoplasmic loop MOTIF: Tyr phosphorylation site {cytoplasmic loop} PEST region SITE: cytoplasmic loop calmodulin binding site SITE: cytoplasmic loop FOR-BINDING-OF: calmodulin transmembrane domain {TM3} exoplasmic loop MOTIF: cysteine residue {C3} MODIFICATION: cysteine residue {C4} cysteine residue {C4} MODIFICATION: cysteine residue {C3} LOOP#: 2 transmembrane domain {TM4} cytoplasmic domain {C-TERMINAL} MISC-INFO: CHANNEL_DIAMETER 1.5-2 NM CONDUCTANCE 100 PS

References

  1. Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 525
  2. Bishop JM. Molecular themes in oncogenesis. Cell. 1991 Jan 25;64(2):235-48. Review. No abstract available. PMID: 1988146
  3. Wang KK et al Calmodulin-binding proteins as calpain substrates. Biochem J 262:693 1989 PMID: 2556106
  4. Lo Turco JJ, Kriegstein AR. (conductance) Clusters of coupled neuroblasts in embryonic neocortex. Science. 1991 Apr 26;252(5005):563-6. PMID: 1850552