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conjugated estrogens (Premarin)/methyltestosterone Estratest
Premarin & methyltestosterone combination.
Indications:
- moderate to severe vasomotor symptoms associated with menopause in patients not responding to estrogen alone
Contraindications:
pregnancy-category X
safety in lactation -
Dosage:
1) 1 tab PO QD for 3 weeks, off for 1 week
2) repeat cycle
0.625 mg of Premarin & 1.25 mg methyltestosterone
0.625 mg of Premarin & 2.5 mg methyltestosterone
Pharmacokinetics: Metabolism: liver
Adverse effects:
1) see premarin & methyltestosterone
2) increased blood pressure, edema, thromboembolism, depression, headache, chloasma, melasma, breast tenderness, change in menstrual flow, hypercalcemia, nausea/vomiting, cholestatic jaundice
Mechanism of action: see premarin & methyltestosterone
Interactions
drug adverse effects of estrogens
General
pharmacologic combination
estrogen
androgen or anabolic steroid
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998 - not on National VA formulary
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
Components
conjugated estrogens (Premarin, Enjuvia, Cenestin)
methyltestosterone (Android, Testred, Metandren, Oretan, Virilon)