condensin-2

Function: 1) establishes mitotic chromosome architecture 2) role in physical rigidity of the chromatid axis 3) regulatory subunits probably regulate complex phosphorylation upon DNA damage, probably by ATM or ATR Structure: - components include: - SMC2 & SMC4 heterodimer, & 3 non SMC regulatory subunits NCAPH2, NCAPD3 & NCAPG2

Related

condensin condensin complex (GO:0000796)

Properties

COMPARTMENT: cell nucleus SUBUNITS: structural maintenance of chromosome 2-like 1 protein COMPARTMENT: cytoplasm cell nucleus MOTIF: ATP-binding site NAME: ATP-binding site SITE: 32-39 coiled coil {173-507} coiled coil {672-926} coiled coil {963-1031} structural maintenance of chromosomes 4-like 1 protein COMPARTMENT: cytoplasm cell nucleus MOTIF: proline-rich region SITE: 18-23 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S22} Ser phosphorylation site {S28} Ser phosphorylation site {S41} proline-rich region SITE: 66-71 MOTIF: proline residue (SEVERAL) ATP-binding site NAME: ATP-binding site SITE: 113-120 coiled coil {272-588} coiled coil {767-1020} Ser phosphorylation site {S1056} coiled coil {1109-1129} condensin-2 complex subunit H2 COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S95} Ser phosphorylation site {S120} Ser phosphorylation site {S200} Ser phosphorylation site {S228} Ser phosphorylation site {S284} Ser phosphorylation site {S319} Ser phosphorylation site {S466} Ser phosphorylation site {S492} protein KIAA0056 MOTIF: HEAT repeat {441-475} Ser phosphorylation site {S531} HEAT repeat {537-572} HEAT repeat {579-610} HEAT repeat {973-1009} coiled coil {1219-1275} Ser phosphorylation site {S1384} Ser phosphorylation site {S1393} condensin-2 complex subunit G2 COMPARTMENT: cell nucleus MOTIF: HEAT repeat {460-498} Thr phosphorylation site {T805} Thr phosphorylation site {T1119}

References

UniProt :accession Q99743

Components

condensin-2 complex subunit G2 (chromosome-associated protein G2, hCAP-G2, CAP-G2, non-SMC condensin 2 complex subunit G2, leucine zipper protein 5, NCAPG2, LUZP5) condensin-2 complex subunit H2 (non-SMC condensin II complex subunit H2, chromosome-associated protein H2, hCAP-H2, kleisin-beta, NCAPH2, CAPH2) protein KIAA0056 (NCAPD3) structural maintenance of chromosome 2-like 1 protein (chromosome-associated protein E, hCAP-E, XCAP-E homolog, SMC2L1, CAPE, SMC2, PRO0324) structural maintenance of chromosomes 4-like 1 protein (chromosome-associated polypeptide C, hCAP-C, XCAP-C homolog, SMC4L1, CAPC, SMC4)