complement factor H-related protein 4; FHR-4 (CFHR4, CFHL4, FHR4)

Function: - role in complement regulation - can associate with lipoproteins & may play a role in lipid metabolism Structure: - glycosylated - homodimer - contains 5 Sushi (CCP/SCR) domains Compartment: secreted Expression: - expressed by the liver & secreted into plasma

General

glycoprotein secreted protein

Properties

SIZE: entity length = 331 aa MW = 37 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-19} Sushi domain {23-85} MOTIF: cysteine residue {C24} MODIFICATION: cysteine residue {C73} cysteine residue {C56} MODIFICATION: cysteine residue {C84} cysteine residue {C73} MODIFICATION: cysteine residue {C24} cysteine residue {C84} MODIFICATION: cysteine residue {C56} Sushi domain {86-147} MOTIF: cysteine residue {C88} MODIFICATION: cysteine residue {C134} cysteine residue {C117} MODIFICATION: cysteine residue {C145} N-glycosylation site {N127} cysteine residue {C134} MODIFICATION: cysteine residue {C88} cysteine residue {C145} MODIFICATION: cysteine residue {C117} Sushi domain {148-206} MOTIF: cysteine residue {C149} MODIFICATION: cysteine residue {C193} cysteine residue {C176} MODIFICATION: cysteine residue {C204} N-glycosylation site {N186} cysteine residue {C193} MODIFICATION: cysteine residue {C149} cysteine residue {C204} MODIFICATION: cysteine residue {C176} N-glycosylation site {N206} Sushi domain {209-267} MOTIF: cysteine residue {C211} MODIFICATION: cysteine residue {C254} cysteine residue {C240} MODIFICATION: cysteine residue {C265} cysteine residue {C254} MODIFICATION: cysteine residue {C211} cysteine residue {C265} MODIFICATION: cysteine residue {C240} Sushi domain {268-331} MOTIF: cysteine residue {C269} MODIFICATION: cysteine residue {C320} cysteine residue {C303} MODIFICATION: cysteine residue {C330} N-glycosylation site {N310} cysteine residue {C320} MODIFICATION: cysteine residue {C269} cysteine residue {C330} MODIFICATION: cysteine residue {C303}

Database Correlations

OMIM 605337 UniProt Q92496 Pfam PF00084 Entrez Gene 10877 Kegg hsa:10877

References

UniProt :accession Q92496