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complement factor H-related protein 1; FHR-1; H factor-like protein 1; H-factor-like 1; H36 (CFHR1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2)
Function:
- might be involved in complement regulation
- can associate with lipoproteins
- may play a role in lipid metabolism
Structure:
- N-glycosylated
- 2 forms: one with a single side chain & the other with two
- contains 5 Sushi (CCP/SCR) domains
Compartment: secreted
Expression: expressed by the liver & secreted in plasma
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 330 aa
MW = 38 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-18}
Sushi domain {22-84}
MOTIF: cysteine residue {C23}
MODIFICATION: cysteine residue {C72}
cysteine residue {C55}
MODIFICATION: cysteine residue {C83}
cysteine residue {C72}
MODIFICATION: cysteine residue {C23}
cysteine residue {C83}
MODIFICATION: cysteine residue {C55}
Sushi domain {85-142}
MOTIF: cysteine residue {C87}
MODIFICATION: cysteine residue {C129}
cysteine residue {C114}
MODIFICATION: cysteine residue {C140}
N-glycosylation site {N126}
cysteine residue {C129}
MODIFICATION: cysteine residue {C87}
cysteine residue {C140}
MODIFICATION: cysteine residue {C114}
Sushi domain {145-203}
MOTIF: cysteine residue {C147}
MODIFICATION: cysteine residue {C190}
cysteine residue {C176}
MODIFICATION: cysteine residue {C201}
cysteine residue {C190}
MODIFICATION: cysteine residue {C147}
N-glycosylation site {N194}
cysteine residue {C201}
MODIFICATION: cysteine residue {C176}
Sushi domain {206-264}
MOTIF: cysteine residue {C208}
MODIFICATION: cysteine residue {C251}
cysteine residue {C237}
MODIFICATION: cysteine residue {C262}
cysteine residue {C251}
MODIFICATION: cysteine residue {C208}
cysteine residue {C262}
MODIFICATION: cysteine residue {C237}
cysteine residue {C266}
MODIFICATION: cysteine residue {C317}
Sushi domain {273-329}
MOTIF: cysteine residue {C300}
MODIFICATION: cysteine residue {C327}
cysteine residue {C317}
MODIFICATION: cysteine residue {C266}
cysteine residue {C327}
MODIFICATION: cysteine residue {C300}
Database Correlations
OMIM 134371
UniProt Q03591
Pfam PF00084
Entrez Gene 3078
Kegg hsa:3078
References
UniProt :accession Q03591