complement component receptor 1-like protein (complement C4b-binding protein CR-1-like protein, CR1L)

Function: - interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3) Structure: - belongs to the receptors of complement activation (RCA) family - contains 8 Sushi (CCP/SCR) domains Compartment: - cytoplasm, membrane, secreted - predominantly found in association with the membrane fraction, but also located in the cytoplasm & in the supernatant Alternative splicing: named isoforms=2 Expression: - expressed in fetal liver & to a lesser extent in fetal spleen & thymus - expression appears to be limited to hematopoietic & fetal lymphoid tissue

General

glycoprotein receptor

Properties

SIZE: entity length = 569 aa MW = 63 kD COMPARTMENT: cytoplasm MOTIF: signal sequence {1-32} Sushi domain {33-93} MOTIF: cysteine residue {C35} MODIFICATION: cysteine residue {C78} N-glycosylation site {N48} cysteine residue {C65} MODIFICATION: cysteine residue {C91} cysteine residue {C78} MODIFICATION: cysteine residue {C35} cysteine residue {C91} MODIFICATION: cysteine residue {C65} Sushi domain {94-155} MOTIF: cysteine residue {C96} MODIFICATION: cysteine residue {C137} cysteine residue {C123} MODIFICATION: cysteine residue {C153} cysteine residue {C137} MODIFICATION: cysteine residue {C96} cysteine residue {C153} MODIFICATION: cysteine residue {C123} Sushi domain {156-226} MOTIF: cysteine residue {C158} MODIFICATION: cysteine residue {C207} cysteine residue {C187} MODIFICATION: cysteine residue {C224} cysteine residue {C207} MODIFICATION: cysteine residue {C158} cysteine residue {C224} MODIFICATION: cysteine residue {C187} Sushi domain {228-287} MOTIF: cysteine residue {C230} MODIFICATION: cysteine residue {C272} cysteine residue {C258} MODIFICATION: cysteine residue {C285} cysteine residue {C272} MODIFICATION: cysteine residue {C230} cysteine residue {C285} MODIFICATION: cysteine residue {C258} Sushi domain {287-347} MOTIF: cysteine residue {C289} MODIFICATION: cysteine residue {C332} cysteine residue {C318} MODIFICATION: cysteine residue {C345} cysteine residue {C332} MODIFICATION: cysteine residue {C289} cysteine residue {C345} MODIFICATION: cysteine residue {C318} Sushi domain {348-410} MOTIF: cysteine residue {C350} MODIFICATION: cysteine residue {C392} cysteine residue {C378} MODIFICATION: cysteine residue {C408} cysteine residue {C392} MODIFICATION: cysteine residue {C350} cysteine residue {C408} MODIFICATION: cysteine residue {C378} Sushi domain {411-472} MOTIF: cysteine residue {C413} MODIFICATION: cysteine residue {C454} cysteine residue {C440} MODIFICATION: cysteine residue {C470} cysteine residue {C454} MODIFICATION: cysteine residue {C413} cysteine residue {C470} MODIFICATION: cysteine residue {C440} Sushi domain {473-543} MOTIF: cysteine residue {C504} MODIFICATION: cysteine residue {C541} cysteine residue {C541} MODIFICATION: cysteine residue {C504}

Database Correlations

OMIM 605886 UniProt Q2VPA4 Pfam PF00084 Kegg hsa:1379

References

UniProt :accession Q2VPA4