C3a anaphylatoxin chemotactic receptor; C3a-R; C3AR (C3AR1 AZ3B C3R1 HNFAG09)

Function: - receptor for the chemotactic & inflammatory peptide anaphylatoxin C3a - stimulates chemotaxis, granule enzyme release & superoxide production - sulfation of Tyr-174 is essential for binding of C3a anaphylatoxin Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, & endothelial cells - mostly expressed in lymphoid tissues

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 482 aa MW = 54 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-23} MOTIF: N-glycosylation site {N9} transmembrane domain {24-46} cytoplasmic loop {47-57} transmembrane domain {58-80} exoplasmic loop {81-96} MOTIF: cysteine residue {C95} MODIFICATION: cysteine residue {C172} transmembrane domain {97-118} cytoplasmic loop {119-139} transmembrane domain {140-160} exoplasmic loop {161-340} MOTIF: cysteine residue {C172} MODIFICATION: cysteine residue {C95} N-glycosylation site {N194} transmembrane domain {341-360} cytoplasmic loop {361-377} transmembrane domain {378-400} exoplasmic loop {401-417} transmembrane domain {418-438} cytoplasmic domain {439-482}

Database Correlations

OMIM 605246 UniProt Q16581 Pfam PF00001 Kegg hsa:719