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complement-1 (C1)

Function: - first component of the complement cascade Stucture: - C1 is a Ca+2-dependent trimolecular complex of C1q, C1r & C1s in the molar ratio of 1:2:2

Interactions

molecular events

Related

complement cascade

General

complement molecular complex

Properties

SIZE: MW = 740 kD COMPARTMENT: plasma MOTIF: Ca+2-binding site EFFECTOR-BOUND: Ca+2 SUBUNITS: complement C1q COMPARTMENT: plasma complement C1r (2) MOTIF: active site glycosylation site EGF domain allosteric site (2) FOR-BINDING-OF: complement C1 inhibitor STATE: Inactive complement C1s (2) CONFIGURATION: dimer MOTIF: active site EGF domain allosteric site (2) FOR-BINDING-OF: complement C1 inhibitor STATE: Inactive

References

  1. Clinical Diagnosis & Management by Laboratory Methods, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1991, pg 831

Component-of

complement complex C14b2b2a3b (C5 convertase)

Components

complement C1q complement C1r complement C1s