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common prescription drugs associated with insomnia
Etiology:
Antihypertensives:
- clonidine
- beta-blockers
- propranolol
- atenolol
- pindolol
- methyldopa
- reserpine
Anticholinergic agents
- ipratropium (Atrovent)
Analeptics
- methylphenidate
Endocrine agents
- oral contraceptives
- thyroxine
- glucocorticoids
- progesterone
Sympathomimetic amines
- bronchodilators
- terbutaline
- albuterol
- salmeterol
- metaproterenol
- theophylline
- decongestants
- phenylpropanolamine
- pseudoephedrine
Antineoplastic agents
- medroxyprogesterone
- leuprolide
- goserelin
- pentostatin
- daunorubicin
- interferon-alpha
Miscellaneous agents
- phenytoin
- nicotine
- levodopa
- quinidine
- caffeine*
* many over the counter products contain caffeine, including aspirin
- cough/cold preparations
- beverages (colas ..)
Management:
- melatonin 2.5 mg nightly decreases sleep latency & increases sleep duration in patients taking beta-blockers [2]
General
drug adverse effect(s) of
References
- Kupfer DJ, Reynolds CF 3rd.
Management of insomnia.
N Engl J Med. 1997 Jan 30;336(5):341-6. Review.
PMID: 9011788
- Scheer FA, Morris CJ, Garcia JI et al
Repeated melatonin supplementation improves sleep in
hypertensive patients treated with beta-blockers: a randomized
controlled trial.
Sleep. 2012 Oct 1;35(10):1395-402.
PMID: 23024438 Free PMC Article