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collectin-10 (collectin liver protein 1, CL-L1, collectin-34, COLEC10, CLL1, UNQ366/PRO702)
Function:
- collectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine
Structure:
- belongs to the COLEC10/COLEC11 family
- contains 1 C-type lectin domain
- contains 1 collagen-like domain
Compartment:
- secreted [1]
- cytoplasm [2]
Expression:
- highly expressed in liver, placenta & adrenal gland
- moderately expressed in small intestine, lung, stomach & prostate
- weakly expressed in trachea & spleen
General
collectin
glycoprotein
secreted protein
Properties
SIZE: entity length = 277 aa
MW = 31 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-27}
Collagen-like {53-112}
C-type lectin {155-271}
MOTIF: cysteine residue {C176}
MODIFICATION: cysteine residue {C270}
cysteine residue {C248}
MODIFICATION: cysteine residue {C262}
N-glycosylation site {N258}
cysteine residue {C262}
MODIFICATION: cysteine residue {C248}
cysteine residue {C270}
MODIFICATION: cysteine residue {C176}
Database Correlations
OMIM 607620
UniProt Q9Y6Z7
PFAM correlations
References
- UniProt :accession Q9Y6Z7
- Ohtani K et al,
Molecular cloning of a novel human collectin from liver (CL-L1).
J Biol Chem. 1999 May 7;274(19):13681-9.
PMID: 10224141