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collagen type-2
Expression:
- hyaline cartilage
- 50% of all cartilage protein
- associated with type-9 collagen
Pathology:
- collagenopathy type-2, collagenopathy type-11
General
collagen
Properties
COMPARTMENT: extracellular matrix
WITHIN: cartilage
vitreous humor
SECRETED-BY: chondrocyte
SUBUNITS: collagen 2 alpha-1 (3)
MOTIF: signal sequence {1-25}
VWFC domain {32-90}
proteolytic site {181-182}
Triple-helical region {201-1214}
Nonhelical region (C-terminal) {1215-1241}
proteolytic site {1241-1242}
Fibrillar collagen NC1 {1253-1487}
MOTIF: N-glycosylation site {N1388}
References
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 920
- Wikipedia, collagen entry
http://en.wikipedia.org/wiki/collagen
Components
collagen 2 alpha-1; contains: chondrocalcin (COL2A1)