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collagen 5 alpha-3 (COL5A3)
Function:
- type 5 collagen is a member of group 1 collagen (fibrillar forming collagen)
- it is a minor connective tissue component of nearly ubiquitous distribution
- type 5 collagen binds to DNA, heparan sulfate, thrombospondin, heparin, & insulin
- type 5 collagen is a key determinant in the assembly of tissue-specific matrices (putative)
- Pro at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains
- trimers of two COL5A1 & one COL5A2 chains in most tissues
- trimers of one COL5A1, oneCOL5A2, & one COL5A3 in placenta
Structure:
- belongs to the fibrillar collagen family
- contains 1 fibrillar collagen NC1 domain
- contains 1 TSP N-terminal (TSPN) domain
Compartment:
- secreted, extracellular space, extracellular matrix (putative)
General
collagen subunit
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 1745 aa
MW = 172 kD
MOTIF: signal sequence {1-29}
TSP N-terminal {31-210}
MOTIF: N-glycosylation site {N102}
N-glycosylation site {N141}
Nonhelical region {211-391}
Triple-helical region {392-1489}
MOTIF: Ser phosphorylation site {S718}
Fibrillar collagen NC1 {1514-1744}
Database Correlations
OMIM 120216
UniProt P25940
PFAM correlations
Entrez Gene 50509
Kegg hsa:50509
References
- UniProt :accession P25940
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 906
Component-of
collagen type-5