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collagen 27 alpha-1 (COL27A1, KIAA1870)
Function:
- role during the calcification of cartilage & the transition of cartilage to bone
Structure:
- belongs to the fibrillar collagen family
- contains 16 collagen-like domains
- contains 1 laminin G-like domain
- contains 1 TSP N-terminal (TSPN) domain
Compartment:
- secreted, extracellular space, extracellular matrix
- found on some small banded collagen fibrils & meshworks (putative)
Alternative splicing: named isoforms=3
Expression:
- detected at E67 in the primary ossification center
- tightly restricted to the pericellular region of the hypertrophic chondrocytes & lacunae at the very center of the future diaphysis
- at fetal 20-week highly abundant in the hypertrophic zone at the chondroosseous junction
- weakly detected around cells in the resting & proliferative zone of the cartilagenous plate, but intense detection occurred deep in the hypertrophic zone near the newly formed bone
- detected throughout the extracellular matrix (ECM)
- closely situated around hypertrophic chondrocytes
General
collagen subunit
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 1860 aa
MW = 187 kD
MOTIF: signal sequence {1-41}
TSP N-terminal {45-222}
Laminin G-like {71-236}
N-glycosylation site {N271}
proline-rich region
SITE: 283-1621
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S419}
Triple-helical region {625-1618}
Collagen-like 1 {625-679}
Collagen-like 2 {688-747}
Collagen-like 3 {748-807}
Collagen-like 4 {808-867}
Collagen-like 5 {871-930}
Collagen-like 6 {931-990}
Collagen-like 7 {1003-1062}
Collagen-like 8 {1066-1125}
Collagen-like 9 {1126-1185}
Collagen-like 10 {1192-1251}
Collagen-like 11 {1258-1317}
Collagen-like 12 {1318-1378}
Collagen-like 13 {1382-1441}
Collagen-like 14 {1442-1501}
Collagen-like 15 {1502-1561}
Collagen-like 16 {1562-1621}
N-glycosylation site {N1769}
Database Correlations
OMIM 608461
UniProt Q8IZC6
PFAM correlations
Entrez Gene 85301
Kegg hsa:85301
References
- UniProt :accession Q8IZC6
- Wikipedia, collagen entry
http://en.wikipedia.org/wiki/collagen