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collagen 22 alpha-1 (COL22A1)
Function:
- acts as a cell adhesion ligand for skin epithelial cells & fibroblasts
Structure:
- belongs to the fibril-associated collagens with interrupted helices (FACIT) family
- contains 16 collagen-like domains
- contains 1 TSP N-terminal (TSPN) domain
- contains 1 VWFA domain
Compartment:
- secreted, extracellular matrix
- cytoplasm (putative)
Alternative splicing: named isoforms=2
Expression:
- restrictive expression is observed at tissue junctions such as the myotendinous junction in skeletal & heart muscle, the articular cartilage-synovial fluid junction, or the border between the anagen hair follicle & the dermis in the skin
- deposited in the basement membrane zone of the myotendinous junction & the hair follicle & associated with the extrafibrillar matrix in cartilage
General
collagen subunit
glycoprotein
secreted protein
Properties
SIZE: entity length = 1626 aa
MW = 161 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-27}
VWFA domain {38-213}
MOTIF: alanine-rich region {161-165}
MOTIF: alanine residue (SEVERAL)
TSP N-terminal {239-427}
MOTIF: N-glycosylation site {N375}
proline-rich region
SITE: 451-1607
MOTIF: proline residue (SEVERAL)
glycine-rich region {481-1603}
Collagen-like 1 {481-520}
Collagen-like 2 {526-565}
Collagen-like 3 {566-625}
Collagen-like 4 {657-708}
Collagen-like 5 {714-773}
Collagen-like 6 {774-833}
Collagen-like 7 {868-922}
Collagen-like 8 {925-984}
Collagen-like 9 {1047-1095}
Collagen-like 10 {1118-1155}
Collagen-like 11 {1156-1215}
Collagen-like 12 {1249-1308}
Collagen-like 13 {1315-1374}
Collagen-like 14 {1387-1446}
Collagen-like 15 {1495-1550}
Collagen-like 16 {1575-1604}
Database Correlations
OMIM 610026
UniProt Q8NFW1
PFAM correlations
Entrez Gene 169044
Kegg hsa:169044
References
- UniProt :accession Q8NFW1
- Wikipedia, collagen entry
http://en.wikipedia.org/wiki/collagen