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collagen 21 alpha-1 (COL21A1, COL1AL, FP633)
a FACIT collagen
Structure:
- belongs to the fibril-associated collagens with interrupted helices (FACIT) family
- contains 6 collagen-like domains
- contains 1 TSP N-terminal (TSPN) domain
- contains 1 VWFA domain
Compartment:
- secreted, extracellular matrix
- cytoplasm
- found in the extracellular matrix component of blood vessel walls & in the cytoplasm of cultured human aortic smooth muscle
Alternative splicing: named isoforms=3
Expression:
- expressed in lymph node, jejunum, pancreas, stomach, trachea, testis, uterus & placenta > brain, colon, lung, prostate, spinal cord,salivary gland & vascular smooth-muscle cells > heart, liver, kidney, bone marrow, spleen, thymus, skeletal muscle, adrenal gland & peripheral leukocytes
- expression in heart was higher in the right ventricle & right atrium than in the left ventricle & left atrium
- highest expression observed at the fetal stage
- expressed by smooth-muscle cells in the artery wall (PDGF-dependent)
- stimulated by platelet-derived growth factor (PDGF)
General
collagen subunit
glycoprotein
secreted protein
Properties
SIZE: entity length = 957 aa
MW = 99 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-22}
VWFA domain {37-211}
MOTIF: N-glycosylation site {N62}
TSP N-terminal {230-412}
Collagen-like 1 {449-508}
Collagen-like 2 {536-595}
Collagen-like 3 {599-658}
Collagen-like 4 {671-730}
Collagen-like 5 {731-785}
Collagen-like 6 {825-882}
Database Correlations
OMIM 610002
UniProt Q96P44
PFAM correlations
Entrez Gene 81578
Kegg hsa:81578
References
- UniProt :accession Q96P44
- Wikipedia, collagen entry
http://en.wikipedia.org/wiki/collagen