collagen 16 alpha-1 (COL16A1)

Function: - role in mediating cell attachment & inducing integrin-mediated cellular reactions, such as cell spreading & alterations in cell morphology - Pro at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains - interacts with FBN1, fibronectin & integrins ITGA1/ITGB1 & ITGA2/ITGB1 - integrin ITGA1/ITGB1 binds to a unique site within COL16A1 located close to its C-terminal end between collagenous domains COL1-COL3 Structure: - glycosylated - homotrimer - 18 different domains - 9 triple-helical domains (COL9 to COL1) - 10 non-triple-helical domains (NC10 to NC1) - numerous interruptions in the triple helix may make COL15A1 either elastic or flexible - belongs to the fibril-associated collagens with interrupted helices (FACIT) family - contains 1 TSP N-terminal (TSPN) domain Compartment: - secreted, extracellular space, extracellular matrix Alternative splicing: named isoforms=2 Expression: - in papillary dermis, component of specialized fibrillin-1- containing microfibrils - in cartilage matrix, localized to a discrete population of thin, weakly banded collagen fibrils in association with other collagens - in the placenta, found in the amnion - within the amnion, it is found in an acellular, relatively dense layer of a complex network of reticular fibers - also located in a fibroblast layer beneath this dense layer - present in tissues in association with other types of collagen - transiently elevated expression during gestation, & decrease at term

General

collagen subunit glycoprotein

Properties

SIZE: entity length = 1604 aa MW = 158 kD MOTIF: signal sequence {1-21} N-glycosylation site {N47} TSP N-terminal {50-231} Nonhelical region (NC10) {232-374} MOTIF: N-glycosylation site {N327} Triple-helical region {375-506} Nonhelical region 9 (NC9) {507-521} Triple-helical region {522-555} MOTIF: Cell attachment {540-542} Nonhelical region 8 (NC8) {556-572} Triple-helical region {573-631} Nonhelical region 7 (NC7) {632-652} Triple-helical region {653-723} Nonhelical region (NC6) {724-738} Triple-helical region {739-876} Nonhelical region (NC5) {877-887} Triple-helical region {888-939} Nonhelical region(NC4) {940-973} Triple-helical region (COL3) {974-988} Nonhelical region (NC3) {989-1011} MOTIF: Cell attachment {1006-1008} Triple-helical region {1012-1433} MOTIF: Cell attachment {1227-1229} Nonhelical region (NC2) {1434-1472} Triple-helical region {1473-1578} Nonhelical region (NC1) {1579-1604}

Database Correlations

OMIM 120326 UniProt Q07092 Pfam PF01391 Entrez Gene 1307 Kegg hsa:1307