collagen 15 alpha-1; contains: endostatin; restin (COL15A1)

Function: - structural protein - stabilizes microvessels & muscle cells, both in heart & in skeletal muscle - cleaved to form endostatin, a peptied that potently inhibits angiogenesis - Pro at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains Structure: - O-glycosylated; with core 1 or possibly core 8 glycans - an N-terminal peptide contains chondroitin sulfate - trimer; disulfide-linked - belongs to the multiplexin collagen family - contains 1 TSP N-terminal (TSPN) domain Compartment: - secreted, extracellular space, extracellular matrix (putative) Expression: - expressed predominantly in internal organs such as adrenal gland, pancreas & kidney

General

collagen subunit glycoprotein

Properties

SIZE: entity length = 1388 aa MW = 142 kD MOTIF: signal sequence {1-25} TSP N-terminal {40-228} Nonhelical region (NC1) {229-555} MOTIF: Thr glycosylation site {T265} N-glycosylation site {N306} N-glycosylation site {N324} consensus repeat {358-408} consensus repeat {409-459} consensus repeat {460-509} consensus repeat {510-555} Triple-helical region (COL1) {556-573} Nonhelical region (NC2) {574-618} Triple-helical region (COL2) {619-732} MOTIF: N-glycosylation site {N687} Nonhelical region (NC3) {733-763} Triple-helical region (COL3) {764-798} Nonhelical region (NC4) {799-822} MOTIF: N-glycosylation site {N807} N-glycosylation site {N814} Triple-helical region (COL4) {823-867} Nonhelical region (NC5) {868-878} Triple-helical region (COL5) {879-949} Nonhelical region (NC6) {950-983} Triple-helical region (COL6) {984-1013} Nonhelical region (NC7) {1014-1027} Triple-helical region (COL7) {1028-1045} Nonhelical region (NC8) {1046-1052} MOTIF: N-glycosylation site {N1046} Triple-helical region (COL8) {1053-1107} Nonhelical region (NC9) {1108-1117} Triple-helical region (COL9) {1118-1132} Nonhelical region (NC10) {1133-1388}

Database Correlations

OMIM 120325 UniProt P39059 PFAM correlations Entrez Gene 1306 Kegg hsa:1306