collagen 14 alpha-1 (undulin, COL14A1)

Function: - adhesion by integrating collagen bundles Structure: - homotrimer - belongs to the fibril-associated collagens with interrupted helices (FACIT) family - contains 8 fibronectin F3 modules - contains 1 TSP N-terminal (TSPN) domain - contains 2 VWFA domains - associated with surface of interstitial collagen fibrils via COL1 domain (putative) - COL2 domain serves as a rigid arm which sticks out from the fibril & protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (putative) - large N-terminal globular interacts with other matrix molecules or cell surface receptors (putative) - Lys at the 3rd position of the G-X-Y tripeptide repeats are hydroxylated; they bind carbohydrates - Pro at the 3rd position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains - may contain numerous Cys involved in intermolecular & intramolecular disulfide bonding Compartment: secreted Alternative splicing: named isoforms=3

General

collagen subunit oligomerizing protein

Properties

SIZE: entity length = 1796 aa MW = 194 kD MOTIF: signal sequence {1-28} fibronectin type III domain or F3 module {29-117} MOTIF: N-glycosylation site {N94} N-glycosylation site {N137} VWFA domain {158-330} fibronectin type III domain or F3 module {352-440} MOTIF: N-glycosylation site {N372} fibronectin type III domain or F3 module {442-532} fibronectin type III domain or F3 module {534-621} fibronectin type III domain or F3 module {623-712} fibronectin type III domain or F3 module {734-826} fibronectin type III domain or F3 module {828-917} fibronectin type III domain or F3 module {921-1005} VWFA domain {1032-1205} Nonhelical region (NC4) {1217-1458} MOTIF: TSP N-terminal {1229-1424} N-glycosylation site {N1384} N-glycosylation site {N1388} Triple-helical region 1 (COL2) {1459-1610} MOTIF: Cell attachment site {1607-1609} Triple-helical region 2 (COL1) {1654-1779}

Database Correlations

OMIM 120324 UniProt Q05707 PFAM correlations Entrez Gene 7373