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colesevelam (Welchol)
Tradname: Welchol
Pregnancy category: apparently safe during pregnancy [2]
Dosage:
- 3.75 g QD or divided BID
Tabs: 625 mg
Adverse effects:
1) better tolerated than older bile acid resins
2) less likely to cause constipation
3) constipation, heartburn, nausea, eructation, bloating
Drug interactions:
- less likely interfere with absorption of other drugs than older bile acid resins
Mechanism of action:
1) bile acid sequestrant
2) lowers LDL-cholesterol by 19%
3) lowers plasma glucose by unknown mechanism [2]
Notes:
Also see cholestyramine.
Cost: $164/30 days (2005)
Interactions
drug adverse effects of anti-hyperlipidemic agents
monitor with bile acid sequestrants
Related
cholestyramine (Questran)
General
bile acid sequestrant
Database Correlations
PUBCHEM cid=160051
References
- Prescriber's Letter 7(9):51 2000
- Medical Knowledge Self Assessment Program (MKSAP) 15, 16
American College of Physicians, Philadelphia 2009, 2012