colchicine/probenecid (ColBENEMID)

colchicine 0.5 mg, probenecid 0.5 g. Indications: - treatment of chronic, recurrent gouty arthritis Contraindications: Pregnancy category D Dosage: - adults: 1) 1 tab QD for 1 week, then 2) 1 tab BID Adverse effects: - not common (1-10%) - flushing, headache, dizziness, rash, alopecia, anorexia, nausea/vomiting, diarrhea, abdominal pain, urinary frequency, aplastic anemia, leukopenia, agranulocytosis, hepatotoxicity including hepatic necrosis, myopathy, peripheral neuritis, uric acid stones, nephrotic syndrome, hypersensitivity reactions Drug interactions: - methotrexate

References

Kaiser Permanente Northern California Regional Drug Formulary, 1998

Components

colchicine (Colcrys, Lodoco) probenecid (Benemid, Probalan)