coiled-coil domain-containing protein 80 (down-regulated by oncogenes protein 1, CCDC80, DRO1, URB, HBE245)

Function: phosphorylated Structure: belongs to the CCDC80 family Compartment: secreted Alternative splicing: named isoforms=3 Expression: - expressed in dermal papilla & dermal fibroblasts (at protein level) - expressed in heart, thymus, placenta, pancreas, colon, epithelium, spleen & osteoblasts - down-regulated in cancer & after osteoblastic differentiation - up-regulated by dihydrotestosterone

General

phosphoprotein secreted protein

Properties

SIZE: MW = 108 kD entity length = 950 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-21} threonine-rich region {347-404} MOTIF: threonine residue (SEVERAL) lysine-rich region {486-610} MOTIF: lysine residue (SEVERAL) coiled coil {560-587}

Database Correlations

OMIM 608298 UniProt Q76M96

References

UniProt :accession Q76M96