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cofilin-2; cofilin, muscle isoform (CFL2)
Function:
- reversible control of actin polymerization & depolymerization (pH-sensitive)
- it has the ability to bind G-actin & F-actin in a 1:1 ratio of cofilin to actin
- major component of intranuclear & cytoplasmic actin rods
- phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal
Structure:
- belongs to the actin-binding proteins ADF family
- contains 1 ADF-H domain
Compartment:
- nucleus matrix (putative)
- cytoplasm, cytoskeleton (putative)
Alternative splicing: named isoforms=2; CFL2a, CFL2b; isoforms are identical at the level of the protein sequence
Expression:
- isoform CFL2b is expressed predominantly in skeletal muscle & heart
- isoform CFL2a is expressed in various tissues
Pathology:
- defects in CFL2 are the cause of nemaline myopathy type 7
Comparative biology:
- in mouse, found in heart, skeletal muscle, testis
General
cofilin
Properties
SIZE: entity length = 166 aa
MW = 19 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S3}
ADF-H {4-153}
MOTIF: Thr phosphorylation site {T6}
Ser phosphorylation site {S24}
nuclear translocation signal {30-34}
Tyr phosphorylation site {Y89}
Database Correlations
OMIM correlations
MORBIDMAP 601443
UniProt Q9Y281
Pfam PF00241
Entrez Gene 1073
Kegg hsa:1073
References
- UniProt :accession Q9Y281
- Wikipedia; Note: cofilin entry
http://en.wikipedia.org/wiki/cofilin