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cofilin
Function:
- cofilin has weak F-actin severing activity
- binds to actin monomers.
- appears to 'nibble' monomer from F-actin leaving free barbed end
- action similar to destrin
- phospholipid binding may reduce affinity for G-actin [1]
- phosphorylation deactivates cofilin; dephosphorylation activates
- phosphorylated by LIMK1
- dephosphorylated by SSH2, SSH3
Interactions
molecular events
Related
destrin; actin-depolymerizing factor; ADF (DSTN ACTDP DSN)
Specific
cofilin-1; cofilin, non-muscle isoform; 18 kD phosphoprotein; p18 (CFL1 CFL)
cofilin-2; cofilin, muscle isoform (CFL2)
General
cytoskeletal protein
Properties
COMPARTMENT: cytoplasm
MOTIF: binding site
FOR-BINDING-OF: G-actin
binding site
FOR-BINDING-OF: phospholipid
References
- Stossel TP.
On the crawling of animal cells.
Science. 1993 May 21;260(5111):1086-94. Review.
PMID: 8493552
- UniProt :accession Q76I76