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Cocaine & amphetamine-regulated transcript protein (CARTPT, CART)
Function:
1) satiety factor closely associated with actions of leptin & neuropeptide Y
2) anorectic peptide inhibiting both normal & starvation- induced feeding
3) completely blocks feeding response induced by neuropeptide Y & regulated by leptin in the hypothalamus
4) promotes neuronal development & survival
Compartment: secreted
Expression:
- hypothalamus
- found in neurons of ventrolateral part of the arcuate nucleus, in external zone of the median eminence, & in terminals in periventricular part of the paraventricular nucleus
- induced by leptin
Pathology:
- defect associated with reduced resting energy expenditure & cosegregates with obesity phenotype
General
secreted protein
Properties
SIZE: MW = 13 kD
entity length = 116 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-27}
cysteine residue {C82}
MODIFICATION: cysteine residue {C100}
cysteine residue {C88}
MODIFICATION: cysteine residue {C108}
cysteine residue {C100}
MODIFICATION: cysteine residue {C82}
cysteine residue {C102}
MODIFICATION: cysteine residue {C115}
cysteine residue {C108}
MODIFICATION: cysteine residue {C88}
cysteine residue {C115}
MODIFICATION: cysteine residue {C102}
Database Correlations
OMIM 602606
MORBIDMAP 602606
UniProt Q16568
Pfam PF06373
References
UniProt :accession Q16568