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coatomer
Function:
1) one of 2 components (ARF & coatomer) necessary for assembly & budding of vesicles mediating biosynthetic transport across GOLGI stack
2) binds to dilysine motifs
3) reversibly associates with Golgi non-clathrin-coated vesicles
4) mediates biosynthetic protein transport from endoplasmic reticulum (ER) via the Golgi to trans Golgi network
5) budding from Golgi membranes
6) retrograde Golgi-to-ER transport of dilysine-tagged proteins
7) recruited by membranes associated with ADP-ribosylation factors
8) Golgi structural integrity
9) processing, activity, & endocytic recycling of LDL receptors
Structure:
- protein complex of 7 distinct subunits (COPs) alpha-COP, beta-COP, beta'-COP, gamma-COP, delta-COP, epsilon-COP, zeta-COP
Compartment:
- cytoplasm, Golgi
- coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it
General
membrane protein
molecular complex
Properties
COMPARTMENT: cellular membrane
MOTIF: membrane region
SUBUNITS: coatomer subunit alpha
MOTIF: WD repeat {7-37}
WD repeat {49-79}
WD repeat {91-121}
WD repeat {133-163}
Ser phosphorylation site {S173}
WD repeat {203-233}
WD repeat {247-277}
MOTIF: Tyr phosphorylation site {Y249}
Ser phosphorylation site {S402}
Ser phosphorylation site {S895}
Ser phosphorylation site {S1035}
coatomer subunit beta
MOTIF: membrane region
coatomer subunit beta'
MOTIF: WD repeat {13-52}
WD repeat {55-94}
WD repeat {97-136}
WD repeat {140-180}
WD repeat {183-224}
WD repeat {227-266}
WD repeat {350-388}
MOTIF: Tyr phosphorylation site {Y354}
WD repeat {390-425}
WD repeat {746-783}
Ser phosphorylation site {S859}
coiled coil {866-891}
coatomer subunit gamma
MOTIF: HEAT repeat {64-101}
HEAT repeat {283-320}
HEAT repeat {322-355}
HEAT repeat {356-392}
ZNF289/ARFGAP2 interaction {609-874}
coatomer subunit delta
MOTIF: membrane region
MHD {268-511}
coatomer subunit epsilon
MOTIF: Ser phosphorylation site {S45}
Ser phosphorylation site {S99}
zeta-COP
MOTIF: membrane region
References
- Orcl L, Palmer DJ, Amherdt M, Rothman JE.
Coated vesicle assembly in the Golgi requires only coatomer
and ARF proteins from the cytosol.
Nature. 1993 Aug 19;364(6439):732-4.
PMID: 8355790
Components
coatomer subunit alpha; alpha-coat protein; alpha-COP; HEP-COP; HEPCOP; contains: xenin; xenopsin-related peptide; contains: proxenin (COPA)
coatomer subunit beta'; beta'-coat protein; beta'-COP; p102 (COPB2)
coatomer subunit beta; beta-coat protein; beta-COP (COPB1, COPB, MSTP026)
coatomer subunit delta; delta-coat protein; delta-COP; Archain (ARCN1)
coatomer subunit epsilon; epsilon-coat protein; epsilon-COP (COPE)
coatomer subunit gamma; gamma-coat protein; gamma-COP (COPG, COPG1)
zeta coatomer subunit (zeta-COP)