coactosin-like protein (COTL1 CLP)

Function: 1) binds to F-actin (Ca⁺²-independent) 2) no direct effect on actin depolymerization 3) interacts with 5-lipoxygenase (Ca⁺²-independent) Structure: 1) belongs to the actin-binding proteins ADF family, coactosin subfamily 2) contains 1 ADF-H domain Expression: - widely expressed - highest levels in placenta, lung, kidney, peripheral blood leukocytes > brain, liver, pancreas

General

cytoskeletal protein phosphoprotein

Properties

SIZE: MW = 16 kD entity length = 141 aa COMPARTMENT: cytoplasm MOTIF: ADF-H {1-129} MOTIF: Ser phosphorylation site {S114}

Database Correlations

OMIM 606748 UniProt Q14019 Pfam PF00241

References

UniProt :accession Q14019