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CNGA2/CNGA4/CNGB1b complex
Function:
- forms the cyclic nucleotide-gated cation channel of olfactory sensory neurons
- Ca+2-calmodulin exerts its inhibitory effect in cAMP sensitivity by binding to IQ-like motif of CNGA4 & preferably binds to the channel in the closed state
- inhibition by PIP3 of the CNG channel probably occurs via CGNA2 binding
Structure:
- subunits: CNGA2, CNGA4, CNGB1b
General
cyclic nucleotide-gated cation channel
molecular complex
Properties
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {N-TERMINAL}
calmodulin binding site
SITE: N-TERMINAL
FOR-BINDING-OF: calmodulin
exoplasmic loop
LOOP#: 1
exoplasmic loop
LOOP#: 2
exoplasmic loop
LOOP#: 3
transmembrane domain (5)
H5 (K+) pore-forming region
transmembrane domain {TM6}
cytoplasmic domain {C-TERMINAL}
cyclic nucleotide-binding site
SITE: C-TERMINAL
SUBUNITS: cyclic nucleotide-gated cation channel 2
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-138}
transmembrane domain {139-159}
exoplasmic loop {160-171}
transmembrane domain {172-192}
cytoplasmic loop {193-224}
transmembrane domain {225-245}
exoplasmic loop {246-274}
transmembrane domain {275-295}
cytoplasmic loop {296-350}
transmembrane domain {351-371}
exoplasmic loop {372-453}
MOTIF: N-glycosylation site {N379}
transmembrane domain {454-474}
cytoplasmic domain {475-662}
MOTIF: cAMP-binding site
SITE: 521-521
cAMP-binding site
SITE: 536-536
cyclic nucleotide-gated cation channel alpha-4
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-33}
transmembrane domain {34-54}
exoplasmic loop {55-65}
transmembrane domain {66-86}
cytoplasmic loop {87-112}
transmembrane domain {113-133}
exoplasmic loop {134-168}
transmembrane domain {169-189}
cytoplasmic loop {190-217}
transmembrane domain {218-234}
exoplasmic loop {235-244}
transmembrane domain {245-265}
cytoplasmic domain {266-575}
MOTIF: IQ-type {292-302}
cyclic nucleotide-binding site
SITE: 348-471
CNGB1B
References
UniProt :accession Q7Z7C8
Components
cyclic nucleotide-gated cation channel 2 (cyclic nucleotide-gated olfactory channel, CNG channel 2, CNG-2, CNG2, CNGA2, CNCG2)
cyclic nucleotide-gated cation channel alpha-4 (CNG channel alpha-4, CNG-4, CNG4, CNGA4)