Search
CMRF35-like molecule 9 (CLM-9, CD300 antigen-like family member G, triggering receptor expressed on myeloid cells 4, TREM-4, CD300LG, CLM9, TREM4, UNQ422/PRO846)
Function:
- receptor which may mediate L-selectin-dependent lymphocyte rollings
- binds SELL in a Ca+2 dependent manner
- binds lymphocyte (putative)
- O-glycosylated with sialylated oligosaccharides
Structure:
- Ig-like V-type domain mediates binding to lymphocyte
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment:
- apical cell membrane, basolateral cell membrane
- endosome, multivesicular body
Alternative splicing: named isoforms=3
Expression:
- highly expressed in heart, skeletal muscle & placenta
General
CD300 family protein
cell surface receptor
glycoprotein
Properties
SIZE: entity length = 332 aa
MW = 36 kD
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-18}
immunoglobulin superfamily domain {19-121}
MOTIF: cysteine residue {C37}
MODIFICATION: cysteine residue {C107}
N-glycosylation site {N96}
cysteine residue {C107}
MODIFICATION: cysteine residue {C37}
ligand-binding site
Thr glycosylation site {T137}
Thr glycosylation site {T143}
Thr glycosylation site {T144}
Thr glycosylation site {T155}
Thr glycosylation site {T161}
Thr glycosylation site {T170}
Thr glycosylation site {T171}
Thr glycosylation site {T177}
Thr glycosylation site {T187}
Thr glycosylation site {T195}
Ser glycosylation site {S196}
Thr glycosylation site {T199}
Thr glycosylation site {T201}
Ser glycosylation site {S202}
Thr glycosylation site {T207}
Ser glycosylation site {S208}
Ser glycosylation site {S213}
Ser glycosylation site {S214}
Ser glycosylation site {S222}
Thr glycosylation site {T223}
Ser glycosylation site {S224}
Thr glycosylation site {T228}
Ser glycosylation site {S229}
Ser glycosylation site {S237}
transmembrane domain {248-268}
Database Correlations
UniProt Q6UXG3
Pfam PF07686
References
UniProt :accession Q6UXG3