CD300B; CMRF35-like molecule 7; CLM-7; CMRF35-A2; CD300 antigen-like family member B; immune receptor expressed on myeloid cells 3; IREM-3; triggering receptor expressed on myeloid cells 5; TREM-5, Leukocyte mono-Ig-like receptor 5; CD300b antigen (CD300LB, CLM7, CMRF35A2, IREM3, LMIR5, TREM5, UNQ2530/PRO6029)

Function: - acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, & also independently by recruitement of GRB2 - interacts with TYROBP, which enhances cell surface expression & activation properties - interacts with GRB2 in the presence of FYN - phosphorylation on Tyr-188 by FYN is required for interaction with GRB2 Structure: - belongs to the CD300 family - contains 1 Ig-like V-type domain (immunoglobulin-like) domain Compartment: cell membrane Expression: expressed exclusively in myeloid lineages

General

CD300 family protein phosphoprotein receptor

Properties

SIZE: entity length = 201 aa MW = 23 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-17} immunoglobulin superfamily domain {18-120} MOTIF: cysteine residue {C36} MODIFICATION: cysteine residue {C104} cysteine residue {C104} MODIFICATION: cysteine residue {C36} transmembrane domain {152-172} MOTIF: lysine residue {158} Tyr phosphorylation site {Y188}

Database Correlations

UniProt A8K4G0 Pfam PF07686 Kegg hsa:1245

References

UniProt :accession A8K4G0