CMRF35-like-molecule 1 (CLM-1, immune receptor expressed on myeloid cells protein 1, IREM-1, immunoglobulin superfamily member 13, IgSF13, NK inhibitory receptor, CD300 antigen-like family member F, CD300LF, CLM1, IGSF13, IREM1, NKIR, UNQ3105/PRO10111)

Function: - receptor which may be involved in functional regulation of myeloid cells - inhibits osteoclast formation - interacts with PTPN6/SHP-1 (Tyr phosphorylation-dependent) - phosphorylated on Tyr Structure: contains 1 Ig-like V-type domain (immunoglobulin-like) Compartment: membrane Alternative splicing: named isoforms=6 Expression: - highly expressed in spleen, peripheral blood leukoctes, monocytes, lung - weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, colon - expressed selectively in monocytes & monocyte-related cells

General

CD300 family protein cell surface receptor immunoglobulin superfamily protein

Properties

SIZE: MW = 32 kD entity length = 290 aa COMPARTMENT: plasma membrane MOTIF: signal sequence {1-19} immunoglobulin superfamily domain {20-126} MOTIF: cysteine residue {C40} MODIFICATION: cysteine residue {C108} cysteine residue {C54} MODIFICATION: cysteine residue {C62} cysteine residue {C62} MODIFICATION: cysteine residue {C54} N-glycosylation site {N88} cysteine residue {C108} MODIFICATION: cysteine residue {C40} transmembrane domain {157-177} Phosphatase-binding {205-205}

Database Correlations

UniProt Q8TDQ1 Pfam PF07686

References

UniProt :accession Q8TDQ1