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CMRF35-H antigen (CMRF35-H9, CMRF-35-H9, CD300a antigen, inhibitory receptor protein 60, IRp60, IRC1/IRC2, NK inhibitory receptor, CD300A, CMRF35H)
Function:
- receptor with role in down-regulation of cytolytic activity in natural killer cells
- upon tyrosine-phosphorylation, interacts with PTN6/SHP-1 & PTPN11/SHP-2
Structure:
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- expressed in natural killer cells, T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes, monocytes
General
CD300 family protein
cell surface receptor
phosphoprotein
Properties
SIZE: MW = 33 kD
entity length = 299 aa
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-17}
immunoglobulin superfamily domain {19-123}
MOTIF: cysteine residue {C36}
MODIFICATION: cysteine residue {C103}
N-glycosylation site {N83}
N-glycosylation site {N92}
cysteine residue {C103}
MODIFICATION: cysteine residue {C36}
transmembrane domain {181-201}
Database Correlations
OMIM 606790
UniProt Q9UGN4
Pfam PF07686
References
UniProt :accession Q9UGN4