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clot lysis time

Normal range: 1) whole blood: lysis in 48-72 hours [2] 2) Thompson: lysis in 2-7 hours [2] 3) euglobulin: lysis > 60 minutes [1] Clinical significance: Whole blood: 1) lysis in < 24 hours indicates significant fibrinolysis 2) lysis in < 2 hours indicates severe fibrinolysis Increases: 1) aminocaproic acid Decreases: 1) fibrinolysis* 2) fibrinolytic therapy 3) chronic liver disease (50% of patients) 4) alpha-2 plasmin* May be normal in DIC if plasminogen has been depleted.. inhibitor [3] * May be normal in DIC if plasminogen has been depleted Interferences: 1) affected by plasma levels of: a) plasminogen activator b) plasminogen c) fibrinolytic inhibitor 2) if fibrinogen is < 50 mg/dL, clot may be difficult to see Specimen: 1) whole clotted blood (37 degrees C) 2) diluted whole blood (Thompson)

General

clinical hematology test

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  2. Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz ed, WB Saunders, Philadelphia, 1995
  3. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 322