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clioquinol (5-chloro-7-iodo-8-hydroxyquinoline)
Indications:
- once used as anti-amoebic agent
Adverse effects:
-> subacute myelo-optico-neuropathy [SMON] (most likely subacute combined degeneration) probably related to vitamin B12 deficiency
Mechanism of action:
- halogenated 8-hydroxyquinoline [1]
- chelates metal ions, binds Zn+2 & Cu+2 with greater affinity than Ca+2 & Mg+2
- lipophilic, freely crosses blood brain barrier
-
Clinical trials:
- never emerged from phase II clinical trial for Alzheimer's disease 3/02
Interactions
drug interactions
General
antiparasitic agent
chelating agent
quinoline; leucoline; chinoleine; 1-benazazine; benzo[b]pyridine
Properties
Database Correlations
PUBCHEM cid=2788
References
- Rizk et al. J Pharmaceutical & Biomedical Analysis 27:813-20,
2002
- Melov S.
'...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease.
Trends Neurosci. 2002 Mar;25(3):121-3; discussion 123-4. Review.
PMID: 11852134
- Wang Y et al
The anti-neurodegeneration drug clioquinol inhibits the aging-
associated protein CLK-1.
J Biol Chem. 2009 Jan 2;284(1):314-23. Epub 2008 Oct 15.
PMID: 18927074
Component-of
clioquinol/cortisol
clioquinol/cortisol/cortistatin