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Clinical Antipsychotic Trials in Intervention Effectiveness (CATIE)
Alzheimer's disease
9 month treatment, blind initially
1) risperidone
2) olanzapine
3) quitiapine
4) citalopram
Protocol mimics routine clinical care
Outcomes:
- CGI, BPRS, NPI, Cornell depression
- ADLs, life quality, caregiver burden, service utilization
- AE, EPS, laboratory testing
- cognition
Results:
1) somewhat greater effectiveness of olanzapine counterbalanced by lower tolerability
2) < 1/2 of patients were compliant with antipsychotic agent
General
clinical trial
References
- Sulzer, D. In: Intensive Course in Geriatric Medicine &
Board Review, Marina Del Ray, CA, Sept 12-15, 2001
- Lieberman JA et al.
Effectiveness of antipsychotic drugs in patients with chronic
schizophrenia.
N Engl J Med 2005 Sep 22; 353:1209-23.
PMID: 16172203
- http://www.clinicaltrials.gov
- CATIE: Clinical Antipsychotic Trials in Intervention
Effectiveness. A Resarch Program Studying Effectiveness and
Outcomes in Schizophrenia and Alzheimer's disease.
http://www.catie.unc.edu/alheimers/index.html
- Prescriber's Letter 12(9): 2005
Role of atypical antipsychotics in treating patients with
Schizophrenia: Are they better than older agents?
Detail-Document#: 211107
(subscription needed) http://www.prescribersletter.com