Search
clevidipine (Cleviprex)
Indications:
- hypertension in hospitalized patients
Contraindications:
- allergy to eggs or soy (contains these)
Dosage:
- start 1-2 mg/hr IV infusion
- titrate to effect, generally 4-6 mg/hr
- maximum dose: 200 g or 1000 mL/24 hours
Injection:
- lipid emulsion supplied in 50 mL & 100 mL glass vials containing 25 mg & 50 mg clevidipine, respectively (0.5 mg per mL)
Pharmacokinetics:
- duration of action: 15 minutes
Dosage adjustment in renal failure: none
Adverse effects:
- not associated with bronchospasm or bradycardia
Mechanism of action:
- blocks Ca+2 entry into arterial smooth muscle cells during depolarization
- diminishes systemic vascular resistance & mean arterial pressure
Notes:
- cost $180 per 25 mg vial (2008)
- lipid emulsion: contains about 2 Kcal/mL
Interactions
drug adverse effects of calcium channel blockers
General
calcium channel blocker (CCB)
dihydropyridine
Database Correlations
PUBCHEM correlations
References
- Prescriber's Letter 15(10): 2008
New Drug: Cleviprex (Clevidipine)
Detail-Document#: 241003
(subscription needed) http://www.prescribersletter.com
- FDA MedWatch, 12/17/2009
Cleviprex (clevidipine butyrate): Recall
http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm194585.htm