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cleavage stimulation factor 77 kD subunit; CSTF 77 kD subunit; CstF-77; CF-1 77 kD subunit (CSTF3)
Function:
- one of multiple factors required for polyadenylation & 3'-end cleavage of mammalian pre-mRNAs homodimer
- component of CSTF complex
- CSTF3 directly interacts with CSTF1 & CSTF2
- interacts with FIP1L1
Structure: contains 9 HAT repeats
Compartment: nucleus
General
nuclear protein
phosphoprotein
protein subunit
Properties
SIZE: entity length = 717 aa
MW = 83 kD
COMPARTMENT: cell nucleus
MOTIF: HAT {45-77}
HAT {79-110}
HAT {117-152}
HAT {163-196}
HAT {221-261}
HAT {271-303}
HAT {319-352}
HAT {354-387}
HAT {458-494}
proline-rich region
SITE: 559-626
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S691}
Database Correlations
OMIM 600367
UniProt Q12996
Pfam PF05843
Entrez Gene 1479
References
- UniProt :accession Q12996
- Kleiman FE & Manley JL
Functional interaction of BRCA1-associated BARD1 with
polyadenylation factor CstF-50
Science 285:1576-9 1999
PMID: 10477523
Component-of
cleavage stimulation factor