cleavage stimulation factor, subunit 2, 64 kD, tau variant (CSTF2T, KIAA0689)

Function: - role in AAUAAA-independent mRNA polyadenylation in germ cells - binds pre-mRNAs - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - contains 1 RRM domain (RNA recognition motif) Compartment: nucleus

General

nuclear protein phosphoprotein protein subunit RNA-binding protein

Properties

SIZE: MW = 64 kD entity length = 616 aa COMPARTMENT: cell nucleus MOTIF: RNP motif NAME: RNP motif SITE: 16-94 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif glycine-rich region {260-556} MOTIF: consensus repeat {418-422} SEQUENCE-IS: M-E-T-R-[AG] consensus repeat {423-427} SEQUENCE-IS: M-E-T-R-[AG] consensus repeat {428-432} SEQUENCE-IS: M-E-T-R-[AG] consensus repeat {433-437} SEQUENCE-IS: M-E-T-R-[AG] consensus repeat {438-442} SEQUENCE-IS: M-E-T-R-[AG] consensus repeat {443-447} SEQUENCE-IS: M-E-T-R-[AG] consensus repeat {448-452} SEQUENCE-IS: M-E-T-R-[AG] consensus repeat {453-457} SEQUENCE-IS: M-E-T-R-[AG] consensus repeat {458-462} SEQUENCE-IS: M-E-T-R-[AG] consensus repeat {505-509} SEQUENCE-IS: G-[AT]-G-[MI]- Q consensus repeat {510-514} SEQUENCE-IS: G-[AT]-G-[MI]- Q consensus repeat {515-519} SEQUENCE-IS: G-[AT]-G-[MI]- Q consensus repeat {520-524} SEQUENCE-IS: G-[AT]-G-[MI]- Q consensus repeat {525-529} SEQUENCE-IS: G-[AT]-G-[MI]- Q consensus repeat {530-534} SEQUENCE-IS: G-[AT]-G-[MI]- Q consensus repeat {535-539} SEQUENCE-IS: G-[AT]-G-[MI]- Q consensus repeat {540-544} SEQUENCE-IS: G-[AT]-G-[MI]- Q consensus repeat {545-549} SEQUENCE-IS: G-[AT]-G-[MI]- Q Ser phosphorylation site {S557} Ser phosphorylation site {S563} Ser phosphorylation site {S567}

Database Correlations

OMIM 611968 UniProt Q9H0L4 Pfam PF00076 Entrez Gene 23283 Kegg hsa:23283

References

UniProt :accession Q9H0L4