cleavage & polyadenylation specificity factor 6 (cleavage & polyadenylation specificity factor 68 kD subunit, CPSF 68 kD subunit, pre-mRNA cleavage factor Im 68-kD subunit, protein HPBRII-4/7, CPSF6, CFIM68)

Function: 1) component of the cleavage factor Im complex (CFIm) 2) pre-MRNA 3'-end poly(A) site cleavage & poly(A) addition in association with CPSF5 3) binds to cleavage & polyadenylation RNA substrates 4) interacts CPSF5, SFRS3, SFRS7, SFRS10, SNRP70 Compartment: - nucleus - in punctate subnuclear structures localized adjacent to nuclear speckles (paraspeckles) Alternative splicing: named isoforms=3

General

nuclear protein phosphoprotein protein subunit RNA-binding protein

Properties

MOTIF: RNA-binding motif FOR-BINDING-OF: ribonucleic acid phosphorylation site

Database Correlations

OMIM 604979 UniProt Q16630 Pfam PF00076

References

UniProt :accession Q16630