cleavage & polyadenylation specificity factor subunit 4; cleavage & polyadenylation specificity factor 30 kD subunit; CPSF 30 kD subunit; NS1 effector domain-binding protein 1; Neb-1; No arches homolog (CPSF4 CPSF30 NAR NEB1)

Function: 1) component of the CPSF complex 2) binds RNA polymers with preference for poly(U) 3) interacts with FIP1L1 4) association with influenza A virus NS1 blocks processing of pre-mRNAs & prevents nuclear export of host cell mRNAs Compartment: nucleus Alternative splicing: named isoforms=3

General

phosphoprotein protein subunit zinc finger protein

Properties

SIZE: entity length = 269 aa MW = 30 kD COMPARTMENT: cell nucleus MOTIF: Zinc finger NAME: Zinc finger SITE: 35-61 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 62-89 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 90-117 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 118-142 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 143-169 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S200} Ser phosphorylation site {S202} Ser phosphorylation site {S211} Ser phosphorylation site {S212} Zn finger C2HC-type SITE: 243-260 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 603052 UniProt O95639 PFAM correlations Entrez Gene 10898 Kegg hsa:10898

References

UniProt :accession O95639