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cleavage & polyadenylation specificity factor subunit 2; cleavage & polyadenylation specificity factor 100 kD subunit; CPSF 100 kD subunit (CPSF2, CPSF100, KIAA1367)
Function:
- component of the CPSF complex involded in pre-mRNA 3'-end formation
- involved in the histone 3'-end pre-mRNA processing
- interacts with CPSF3, CSTF2 & SYMPK
Structure:
- belongs to the metallo-beta-lactamase superfamily RNA-metabolizing metallo-beta-lactamase-like family, CPSF2/YSH1 subfamily
Compartment: nucleus (putative)
General
nuclear protein
phosphoprotein
protein subunit
RNA-binding protein
Properties
SIZE: entity length = 782 aa
MW = 88 kD
COMPARTMENT: cell nucleus
MOTIF: Tyr phosphorylation site {Y395}
Ser phosphorylation site {S412}
Ser phosphorylation site {S419}
Ser phosphorylation site {S420}
Ser phosphorylation site {S423}
Ser phosphorylation site {S660}
Database Correlations
OMIM 606028
UniProt Q9P2I0
Pfam PF07521
Entrez Gene 53981
Kegg hsa:53981
References
- UniProt :accession Q9P2I0
- OMIM :accession 606028
Component-of
cleavage & polyadenylation specificity factor (CPSF) complex