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cleavage & polyadenylation specificity factor subunit 1; cleavage & polyadenylation specificity factor 160 kD subunit; CPSF 160 kD subunit (CPSF1, CPSF160)
Function:
- component of the CPSF complex involded in pre-mRNA 3'-end formation
- this subunit is involved in the RNA recognition step of the polyadenylation reaction
- found in a complex with CPSF1, FIP1L1 & PAPOLA
- interacts with FIP1L1, PAPD4/GLD2 & SRRM1
Structure:
- belongs to the CPSF1 family
- the N-terminus is blocked
Compartment: nucleus, nucleoplasm
General
nuclear protein
phosphoprotein
protein subunit
RNA-binding protein
Properties
SIZE: entity length = 1443 aa
MW = 161 kD
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T739}
nuclear translocation signal {893-908}
Database Correlations
OMIM 606027
UniProt Q10570
Pfam PF03178
Entrez Gene 29894
Kegg hsa:29894
References
- UniProt :accession Q10570
- OMIM :accession 606027
Component-of
pre-mRNA cleavage complex 2 (pre mRNA 3' end processing complex)