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cleavage & polyadenylation specificity factor (CPSF) complex
Function:
1) mRNA 3'polyadenylation
2) recognizes AAUAAA signal sequence.
3) in concert with poly[A]polymerase, facilitates 3' polyadenylation of mRNA
Structure:
- components include: CPSF1, CPSF2, CPSF3, CPSF4, FIP1L1
General
adenine phosphoribosyltransferase (APRT)
multisubunit protein
nuclear protein
RNA-binding protein
Properties
COMPARTMENT: cell nucleus
MOTIF: active site
RNA-binding motif
FOR-BINDING-OF: ribonucleic acid
SUBUNITS: cleavage & polyadenylation specificity factor subunit 1
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T739}
nuclear translocation signal {893-908}
cleavage & polyadenylation specificity factor subunit 2
COMPARTMENT: cell nucleus
MOTIF: Tyr phosphorylation site {Y395}
Ser phosphorylation site {S412}
Ser phosphorylation site {S419}
Ser phosphorylation site {S420}
Ser phosphorylation site {S423}
Ser phosphorylation site {S660}
cleavage & polyadenylation specificity factor subunit 3
COMPARTMENT: cell nucleus
MOTIF: Zn+2-binding site
SITE: 71-71
Zn+2-binding site
SITE: 73-73
Zn+2-binding site
SITE: 75-75
Zn+2-binding site
SITE: 76-76
Zn+2-binding site
SITE: 158-158
Zn+2-binding site
SITE: 179-179
histidine residue {H396}
Zn+2-binding site
SITE: 418-418
Thr phosphorylation site {T681}
cleavage & polyadenylation specificity factor subunit 4
COMPARTMENT: cell nucleus
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 35-61
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 62-89
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 90-117
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 118-142
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 143-169
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S200}
Ser phosphorylation site {S202}
Ser phosphorylation site {S211}
Ser phosphorylation site {S212}
Zn finger C2HC-type
SITE: 243-260
EFFECTOR-BOUND: Zn+2
pre-mRNA 3'-end-processing factor FIP1
COMPARTMENT: cell nucleus
MOTIF: PAPOLA {1-356}
MOTIF: binding site
SITE: 1-111
FOR-BINDING-OF: poly(A) polymerase alpha
BINDING-STIE
:SITE RANGE
:LOW 137
:HIGH 243
:FOR_BINDING_OF CPSF4
Ser phosphorylation site {S259}
proline-rich region
SITE: 356-406
MOTIF: proline residue (SEVERAL)
CPSF1/CSTF3
NAME: CPSF1/CSTF3
SITE: 443-594
FOR-BINDING-OF: cleavage & polyadenylation specificity factor subunit 1
cleavage stimulation factor 77 kD subunit
MOTIF: arginine-rich region {456-562}
MOTIF: arginine residue (SEVERAL)
glutamate-rich region {478-594}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S554}
References
UniProt :accession 606027, 606028, 606029
Components
cleavage & polyadenylation specificity factor subunit 1; cleavage & polyadenylation specificity factor 160 kD subunit; CPSF 160 kD subunit (CPSF1, CPSF160)
cleavage & polyadenylation specificity factor subunit 2; cleavage & polyadenylation specificity factor 100 kD subunit; CPSF 100 kD subunit (CPSF2, CPSF100, KIAA1367)
cleavage & polyadenylation specificity factor subunit 3; cleavage & polyadenylation specificity factor 73 kD subunit; CPSF 73 kD subunit; mRNA 3'-end-processing endonuclease CPSF-73 (CPSF3, CPSF73)
cleavage & polyadenylation specificity factor subunit 4; cleavage & polyadenylation specificity factor 30 kD subunit; CPSF 30 kD subunit; NS1 effector domain-binding protein 1; Neb-1; No arches homolog (CPSF4 CPSF30 NAR NEB1)
pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1, factor interacting with PAP, hFip1, rearranged in hypereosinophilia, FIP1L1, FIP1, RHE)