Search
class B basic helix-loop-helix protein 8; bHLHB8; muscle, intestine & stomach expression 1; MIST-1 (BHLHB8, MIST1, BHLHA15)
Function:
1) role in controlling transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated
2) transcriptional repression via muscle-specific E-box occupancy by homodimers
3) negatively regulates bHLH-mediated transcription through an N-terminal repressor domain (putative)
4) regulator of acinar cell function, stability, & identity
5) required for normal organelle localization in exocrine cells & for mitochondrial Ca+2 transport
6) regulator of gene expression in several different embryonic & postnatal cell lineages
7) binds to the E-box consensus sequence 5'-CANNTG-3'
8) forms homodimers or heterodimers with TCF3 gene products E12 & E47 - these dimers bind to the E-box site
9) heterodimer with MYOD1 does NOT bind target DNA
Structure:
1) lacks a classic transcription activation domain
2) N-terminal region capable of inhibiting heterologous activators
3) contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus
Expression:
- expressed in brain, liver, spleen, skeletal muscle
General
DNA-binding protein
Properties
SIZE: MW = 21 kD
entity length = 189 aa
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 57-77
helix-loop-helix
NAME: helix-loop-helix
SITE: 78-128
FOR-BINDING-VIA: helix-loop-helix
Database Correlations
OMIM 608606
UniProt Q7RTS1
Pfam PF00010
References
UniProt :accession Q7RTS1