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class B basic helix-loop-helix protein 5; trinucleotide repeat-containing gene 20 protein (BHLHB5, BHLHE22,TNRC20)
Function:
- inhibits DNA binding of TCF3/E47 homodimers & TCF3 (E47)/NEUROD1 heterodimers
- strong repressor of Neurod1 & Myod-responsive genes, probably by heterodimerization with class A basic helix-loop-helix factors
- despite presence of an intact basic domain, does not bind to DNA
Structure: contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus
Expression: brain-specific, highest expression in cerebellum
General
basic helix loop helix (bHLH) family transcription factor
Properties
SIZE: MW = 37 kD
entity length = 381 aa
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {56-60}
MOTIF: serine residue (SEVERAL)
glycine-rich region {72-225}
serine-rich region {208-234}
MOTIF: serine residue (SEVERAL)
DNA-binding motif
SITE: 235-254
helix-loop-helix
NAME: helix-loop-helix
SITE: 255-297
FOR-BINDING-VIA: helix-loop-helix
alanine-rich region {315-357}
MOTIF: alanine residue (SEVERAL)
Database Correlations
UniProt Q8NFJ8
References
UniProt :accession Q8NFJ8